魏引　何亞磊　蔡葉銳　周季　張鑫　常業(yè)飛

[摘要] 目的 研究血清胎盤生長因子（PlGF）在慢性心力衰竭患者中的應(yīng)用效果，為臨床相關(guān)診治提供參考。 方法 選取2015年1～3月云南省第三人民醫(yī)院（以下簡稱“我院”）收治的慢性心力衰竭患者85例作為觀察組，同期選取我院參加健康體檢的60名健康者作為對照組。采用酶聯(lián)免疫吸附法（ELISA法）檢測兩組患者PlGF、高敏C-反應(yīng)蛋白（hs-CRP）及腫瘤壞死因子-α（TNF-α）含量，各心功能分級血清指標(biāo)含量，并對觀察組患者進(jìn)行對癥治療，其后再比較各血清指標(biāo)變化。 結(jié)果 觀察組治療前血清PlGF、hs-CRP及TNF-α含量均高于對照組，差異均有統(tǒng)計學(xué)意義（P < 0.05）;隨著患者心功能分級增高，其血清PlGF、hs-CRP及TNF-α含量均升高，差異均有統(tǒng)計學(xué)意義（P < 0.05）;觀察組治療后血清PlGF、hs-CRP及TNF-α含量低于治療前，差異均有統(tǒng)計學(xué)意義（P < 0.05）。 結(jié)論 慢性心力衰竭患者血清PlGF、hs-CRP及TNF-α含量均較健康者升高，且隨著心功能分級增高而上升，經(jīng)對癥治療，可有效改善患者上述指標(biāo)，為臨床診治提供重要參考。

[關(guān)鍵詞] 血清胎盤生長因子;高敏 C-反應(yīng)蛋白;腫瘤壞死因子-α;慢性心力衰竭

[中圖分類號] R541.6? ? ? ? ? [文獻(xiàn)標(biāo)識碼] A? ? ? ? ? [文章編號] 1673-7210（2019）06（b）-0039-04

Application effect of serum placental growth factor in patients with chronic heart failure

WEI Yin? ?HE Yalei? ?CAI Yerui? ?ZHOU Ji? ?ZHANG Xin? ?CHANG Yefei

Department of Cardiology， the Third People′s Hospital of Yunnan Province， Yunnan Province， Kunming? ?650000， China

[Abstract] Objective To study the effect of serum placental growth factor （PlGF） in patients with chronic heart failure， and to provide reference for clinical diagnosis and treatment. Methods Eighty-five patients with chronic heart failure admitted to the Third People′s Hospital of Yunnan Province （“our hospital” for short） from January to March 2015 were selected as the observation group， and 60 healthy patients who participated in the physical examination in our hospital were selected as the control group. Enzyme-linked immunosorbent assay （ELISA） was used to detect the levels of PlGF， hs-CRP and TNF-α in the two groups. The serum indexes of each cardiac function grade were measured. The patients in the observation group were treated symptomatically， and then the changes of serum indexes were compared. Results The serum levels of PlGF， hs-CRP and TNF-α in the observation group were higher than those in the control group before treatment， and the differences were statistically significant （P < 0.05）. The serum levels of PlGF， hs-CRP and TNF-α in the observation group increased with the increase of cardiac function grade， and the differences were statistically significant （P < 0.05）. The serum levels of PlGF， hs-CRP and TNF-α in the observation group after treatment were lower than those before treatment， and the differences were statistically significant （P < 0.05）. Conclusion The serum levels of PlGF， hs-CRP and TNF-α in patients with chronic heart failure are higher than those in healthy people， and increase with the increase of cardiac function grade. Symptomatic treatment can effectively improve the above-mentioned indicators of patients and provide important reference for clinical diagnosis and treatment.

綜上所述，慢性心力衰竭患者血清PlGF、hs-CRP及TNF-α含量均較健康者升高，且隨著心功能分級增高而升高，經(jīng)對癥治療，可有效改善患者上述指標(biāo)，可為臨床診治提供重要參考。

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