宋晨光

[摘要] 目的 探討曲美他嗪治療老年冠心病心絞痛合并高血脂患者的效果。 方法 選擇我院從2014年8月～2016年11月間收治的老年冠心病心絞痛合并高血脂患者58例作為研究對(duì)象，按照患者入院日期單雙號(hào)隨機(jī)分組方案，將其分為兩組，分別為對(duì)照組和實(shí)驗(yàn)組；對(duì)照組患者采用硝苯地平緩釋片進(jìn)行治療，而實(shí)驗(yàn)組患者在對(duì)照組的用藥基礎(chǔ)上加入曲美他嗪對(duì)患者進(jìn)行治療；對(duì)比兩組患者的冠心病心絞痛發(fā)作狀況，評(píng)價(jià)其治療有效性，同時(shí)記錄患者的總膽固醇（TC）和甘油三酯（TG）變化，對(duì)比兩組患者的治療結(jié)果。 結(jié)果 實(shí)驗(yàn)結(jié)果顯示，實(shí)驗(yàn)組患者的冠心病治療總有效率明顯優(yōu)于對(duì)照組，組間差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。但兩組患者治療后血脂狀況未獲得明顯改善，治療前后和兩組間比較差異均無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。 結(jié)論 應(yīng)用曲美他嗪對(duì)冠心病心絞痛進(jìn)行治療，具有較好的治療效果，但如果應(yīng)用于老年冠心病心絞痛合并高血脂患者的治療時(shí)，還需要應(yīng)用相應(yīng)的降血脂藥物對(duì)患者進(jìn)行治療，才能保證患者的治療效果，從而提高患者的恢復(fù)狀況。

[關(guān)鍵詞] 曲美他嗪；冠心??；心絞痛；高血脂

[中圖分類(lèi)號(hào)] R541.4 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2018）07-0034-03

[Abstract] Objective To investigate the effectiveness of trimetazidine in elder patients with coronary heart disease and angina pectoris combined with hyperlipidemia. Methods 58 patients with coronary heart disease and angina pectoris combined with hyperlipidemia in our hospital from August 2014 and November 2016 were selected and randomized into control group and experimental group according to the odd-even admission date. Patients in control group were treated with nifedipine sustained release tablets. Patients in experimental group were given additional trimetazidine. The attacks of angina pectoris in patients of two groups were compared to evaluate the effectiveness of the treatment. The changes of total cholesterol（TC） and triglyceride（TG） were recorded to compare the treatment outcome. Results It showed the effectiveness of coronary heart disease treatment in experimental group was significantly better than that in control group（P<0.05）. The levels of blood cholesterol after treatment were not improved significantly in both of two groups compared with the levels before treatment， nor were significant difference found between two groups（P>0.05）. Conclusion The effectiveness of trimetazidine in patients with coronary heart disease and angina pectoris is good. However， it is necessary to combine cholesterol-lowering drugs with trimetazidine in the treatment of elder patients with coronary heart disease and angina pectoris combined with hyperlipidemia to assure the effectiveness and improve the recovery of patients.

[Key words] Trimetazidine； Coronary heart disease； Angina pectoris； Hyperlipidemia

冠心病是臨床常見(jiàn)的一種心臟病，多是因?yàn)榛颊咝募?nèi)出現(xiàn)缺血缺氧或者心肌壞死的狀況所產(chǎn)生[1]。而高血脂則是隨著人們生活質(zhì)量的不斷提升，飲食不規(guī)律或者作息不規(guī)律所產(chǎn)生的一種疾病，臨床發(fā)生率相對(duì)較高，對(duì)患者影響較大，在部分狀況下，如果未對(duì)其進(jìn)行及時(shí)控制，還會(huì)引發(fā)大腦心臟腎臟等組織出現(xiàn)系列并發(fā)癥，嚴(yán)重威脅患者生命安全[2]。且根據(jù)當(dāng)前的臨床資料顯示，高血脂患者的數(shù)量有明顯增加的趨勢(shì)。而高血脂的存在有可能誘發(fā)冠心病，冠心病的存在多會(huì)引發(fā)高血脂，故而臨床將高血脂與冠心病互相視為危險(xiǎn)因素[3]。冠心病合并高血脂患者的治療難度較大，且預(yù)后不佳，嚴(yán)重危害患者生命安全[4]。因此臨床對(duì)于其用藥與護(hù)理均相對(duì)重視。曲美他嗪是常用的治療冠心病的藥物，其效果相對(duì)較好。本次研究中選擇我院從2014年8月～2016年11月間收治的老年冠心病心絞痛合并高血脂患者58例作為研究對(duì)象，探討曲美他嗪用于老年冠心病心絞痛合并高血脂患者的治療效果。