Dear Editor,

W e are writing this letter to present a rare case of bilateral acute depigmentation of the iris (BADI).The case of BADI has not reported in China before, and this case report can help ophthalmologists to identify the clinical features of this disease. Written informed consent was obtained about the use of medical record for the case report from this patient. This case study adhered to tenets of Declaration of Helsinki.

就現(xiàn)實而言，普通話水平測試在制度體系和管理體系的規(guī)范性上的實效性不強(qiáng)，這也直接降低了普通話水平測試工作的整體發(fā)展。此項研究維度雖然是理論層面，但科學(xué)全面的理論研究最終導(dǎo)向于實踐活動，即形成一套針對培訓(xùn)工作的切實可行方法論。

On August 15, 2020, a 28-year-old man initially visited our outpatient department of ophthalmology with the complaint of sudden redness, pain, and photophobia in both eyes for two days, accompanied by lacrimation, foreign body sensation and slightly decreased vision. On July 16, 2020, the patient was treated with levofloxacin ear drops (1 drop, both ears, Tid) and oral moxifloxacin hydrochloride tablets (400 mg, Qd) because of diagnosed tympanitis of both ears. The symptoms were alleviated after 7d of treatment.

Ophthalmic examination: best-corrected visual acuity(BCVA) was 0.6 in the both eyes (no ametropia), and there was ciliary and conjunctival congestion in both eyes (Figure 1).Both corneas were transparent with visible dusty keratic precipitates (KPs). These KPs were formed by pigment granules and deposited on the infero-posterior surface of corneas. The anterior chamber (AC) had a normal depth and contained scattered, floating pigment granules. There was diffuse depigmentation in the anterior surface of the iris in both eyes (Figure 1), with normal pupil size and pupillary light reflex, without pupil conglutination. The lens, optic disc, and retina were normal. Intraocular pressure (IOP) was 9.0 mm Hg in the right eye and 7.7 mm Hg in the left eye [noncontact tonometer (NCT)]. Gonioscopy examination showed substantial pigment deposition in the inferior AC angle in both eyes (Figure 2). Ultrasound biomicroscopy (UBM; SUOER,SW-3200L, China) showed that the diffuse depigmentation was located in iris stroma, and a small number of enhanced spot echoes located in the AC (Figure 2). Optical coherence tomography (OCT, Carl Zeiss, Germany) revealed a normal optic disc and posterior pole of retina. He was treated mainly with dexamethasone eye drops and eye ointment (TobraDex,Novartis, China), of which eye drops were given 3 times a day and eye ointment was given once at bedtime in both eyes.After 10d of treatment, symptoms of both eyes were alleviated gradually. The BCVA of his bilateral eyes recovered to 1.0, the ciliary congestion was alleviated, and pigmental KP was still observed in the posterior surface of the cornea. The floating pigmentation in the aqueous humour was reduced, and no further depigmentation in the iris was observed by slit lamp examination. The IOP (NCT) was 13.2 mm Hg in the right eye and 14.5 mm Hg in the left eye.

On September 3, 2020, the patient complained of recurrent tympanitis and was treated with levofloxacin ear drops(1 drop, both ears, Tid) and moxifloxacin hydrochloride tablets(400 mg, Qd) again. There was no organism isolated by ENT specialist in this case because patient’s symptoms were relieved significantly after empirical broad-spectrum antimicrobial therapy. On September 16, 2020, patient revisited outpatient department with a recurrence of redness, pain, and moderate photophobia in both eyes. Ophthalmic examinations were same as the first episode of attack. The laboratory tests performed on the patient showed that immunoglobulin G (IgG) antibodies against herpes simplex virus type I and II, rubella virus and human cytomegalovirus were elevated, but immunoglobulin M(IgM) antibodies were within the reference ranges. After 3wk of treatments by dexamethasone eye drops and eye ointment,the symptoms of both eyes were relieved gradually. Both eyes’BCVA recovered to 1.0, the ciliary congestion was alleviated.Less dusty KPs deposited on the posterior surface. The floating pigmentation granules in AC was reduced but the iris depigmentation was observed persistently. The ear and ocular symptoms did not recur at the 4-month follow-up. The patient felt satisfied with the effect of the treatment.

According to World Health Organization criteria, the relationship between fluoroquinolone (FQL) therapy and uveitis is“possible”. Hinkle

put forward that clinicians should be aware of a possible bilateral fluoroquinolone-associated uveitis, particularly the finding of iris transillumination and pigment dispersion. In this case, patient presented symptoms of BADI on two separate occasions following the use of high doses of FQL for tympanitis. Integrating with other case reports worldwide, we speculated that the occurrence of BADI may be related to the use of FQL, especially moxifloxacin,but the specific mechanism has been not clear yet. Clinicians should warn the patient and other disciplines against the use of FQL in patients who have a history of BADI, which can reduce the risk of BADI occurrence and relapse.

Through a search of PubMed, CNKI, Wanfang, and other literature platforms, it was found that this case was the first BADI patient reported in China. There are few reports on the disease, and according to its clinical features, it is easily confused with some existing uveal diseases. With missed diagnosis in the clinic, the actual number of cases may be higher than that reported in the literature. Through the reporting and analysis of the clinical features and aetiology,we hope that the diagnosis of the disease can be standardized so that we can fully and correctly recognize it and reduce the misdiagnosis of BADI. At present, the causes and pathogenesis of the disease are not well understood, and increasingly indepth studies on the pathogenesis of BADI are needed to clarify its real aetiology and pathogenesis in the future.

井點系統(tǒng)全部安裝完畢后，需進(jìn)行試驗抽水，以檢查有無漏氣現(xiàn)象，井點運行后必須連續(xù)工作，因此，要準(zhǔn)備好備用電源及電動機(jī)。確保真空泵正常運轉(zhuǎn)，且應(yīng)在水泵進(jìn)水管和出水管口分別安裝真空表和壓力表，在抽水時應(yīng)檢查整個管網(wǎng)的真空度，應(yīng)達(dá)到 550mmHg（73.33kPa）[3]。

Some researches supported the theory of viral hypothesis.Tugal-Tutkun

performed a viral serological examination in 10 of 26 cases of BADI. Antibodies against cytomegalovirus were positive in 10 cases. Maestrini

reported significant improvement in ocular symptoms after antiviral therapy in a patient diagnosed with BADI, which supported the viral infection theory of the disease. The collection of aqueous humor samples by AC paracentesis for viral DNA/RNA analysis was considered. However, the patient declined the procedure because of his symptoms alleviated after effective treatment. The laboratory examination of the patient showed IgG antibodies against herpes simplex virus type I and II, and rubella virus and human cytomegalovirus were found to be elevated. We speculate that there may be a correlation between the occurrence of the disease and viral infection.

We believed that the patient’s clinical symptoms and ophthalmological examinations were consistent with the diagnostic criteria of the rare disease, BADI, reported worldwide before. The first report of BADI was proposed by Turkish Tugal-Tutkun and Urgancioglu

in 2006, followed by scattered cases reported in Turkey, India, the Netherlands,Belgium, Spain, France, Brazil, and the United States. There is no relevant article reported in China according to the database query, and this case may be the first one reported in China.Current clinical case reports indicate that the symptoms of the disease mainly include acute attacks of severe photophobia,eye redness, eye pain, and decreased visual acuity in both eyes

. Ophthalmic examination revealed symmetrical diffuse or patchy depigmentation in the iris stroma, floating pigment granules in the AC, a small amount of pigmentary KPs depositing on the posterior surface of cornea, substantial pigment deposition in surface of trabecular meshwork, round and equal pupils in the bilateral eyes with normal light reflex,and often, fundus showed no significant abnormalities

.

According to the medical history of this patient, it can be speculated that the occurrence of the disease may be related to inflammation. The source of inflammation may be related to tympanitis, which has not been reported in the previous literature. However, the specific pathogenesis still needs further in-depth study.

BADI needs to be differentiated from the bilateral acute iris transillumination (BAIT), which is also a new clinical condition. Patients with BAIT generally present with acute ocular pain, photophobia, and red eyes, with greater intensity than that in BADI. BAIT is characterized by severe transillumination of the iris and acute onset of melanin granules in the AC. Moreover, it is also characterised by mydriatic pupils, unresponsiveness or poor responsiveness to light, and temporary ocular hypertension. The melanin granules of BAIT seem to be shed from the iris pigment epithelium, but BADI is characterized by a depigmentation of the stroma

. The patient’s symptoms seemed to be more in line with the diagnostic criteria of BADI. BADI needs to be differentiated from pigment dispersion syndrome (PDS). It is widely accepted that posterior bowing of the iris resulting in irido-zonular friction and subsequent pigment liberation is the underlying cause of PDS. With most of the trabecular meshwork blocked by melanin granules, the IOP of PDS patients may be elevated and develop pigmentary glaucoma

.In this reported case, UBM showed that the stroma of the iris was deficient, and without iris bowing, the anterior and posterior lens capsules had no pigmentation. Therefore, the clinical diagnosis in this case was not consistent with PDS.

（1）建筑物臨邊防護(hù)管理：本工程施工現(xiàn)場所有的臨邊區(qū)域均設(shè)置防護(hù)欄桿，采用成型的φ48-51×3.5mm鋼管搭設(shè)。對于臨邊區(qū)域下放有人員通過的區(qū)域，還對欄桿進(jìn)行了全面的安全網(wǎng)密封處理，避免墜物傷人。

Supported by the National Natural Science Foundation of China (No.81960175); Guizhou Science and Technology Department (No.[2017]5718; No.[2019]1268);Department of Health of Guizhou Province (No.gzwjkj2017-1-042).

None;

None;

由于具體國情和社會制度等各方面的原因，中國的社會主義協(xié)商民主和西方的協(xié)商民主存在著較大的差異，從而使二者在多個方面呈現(xiàn)出截然不同的相異點。

None;

None.

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