TO THE EDlTOR

I read with great interest the paper by Wang

[1]in the issue 13 of World Journal of Gastrointestinal Oncology,a review article regarding the association between intestinal neoplasms and celiac disease.The authors showed that the total risk of small bowel cancer(SBC)and enteropathy-associated T cell lymphoma(EATL)increased in celiac disease(CD)patients.I have agreed with the authors opinions and they mainly mentioned EATL type I,which is associated with CD.The pathogenesis of EATL remains limited,however,as the authors mentioned in the manuscript that CD disrupts cell-level regulation and chronic intestinal inflammation,which leads to the proliferation of intestinal intraepithelial lymphocytes.The presence of chronic inflammation leads to increase the turnover of cell cycle and contribute to the development of neoplasm due to gene mutation in oncogenes or tumor suppressor genes in EATL.

We previously showed that c-myc mutation was seen in EATL type 2[2].Our findings support that gene mutation is one of the factors developing malignant neoplasm in the absence of celiac disease.JAK/STAT3 signaling pathway was also reported as the main drivers of CD associated lymphomagenesis[3].JAK/STAT pathway regulates MYC expression[4],which lead to proliferation of malignant cells.

The gentleman stared with open mouth at the astonishing sight; but he had given his word to sell the house, so he took his money, as he was told, and went away with his wife to look for some place to live in

CD is one of the significant gastrointestinal diseases and increases the risk of malignant neoplasms.In addition to CD,we believe that other underlying mechanisms contribute to the developing malignant neoplasms[3].We believe that these facts would be a helpful to understand CD and EATL and these findings are highly pertinent and provide a context that helps understand those reported by Wang

[1].

FOOTNOTES

Okumura K performed writing the paper.

The authors have declared no conflicts of interest.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial(CC BYNC 4.0)license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is noncommercial.See:https://creativecommons.org/Licenses/by-nc/4.0/

Kenji Okumura 0000-0002-7751-2624.

My mother was livid. My grandmother had that self-satisfied look of someone who has thrown down an unbeatable trump12 card. I can do what I want, Ellen, and you can t stop me. My mother glared at her mother. She glared at me. No one can glare like my mother. If there were a glaring Olympics, she would undoubtedly13 win the gold medal.

United States

When Muriel and I reached our little garden and sat down, his words came back to me. God had spoken through an inebriated18 old derelict. It is you who is whispering to my spirit, I likes it, tha s good, I said aloud. I may be on the bench, but if you like it and say it s good, that s all that counts.

Wang LL

A

Wang LL

1 Wang M,Yu M,Kong WJ,Cui M,Gao F.Association between intestinal neoplasms and celiac disease:A review.

2021;13:1017-1028[PMID:34616509 DOI:10.4251/wjgo.v13.i9.1017]

2 Okumura K,Ikebe M,Shimokama T,Takeshita M,Kinjo N,Sugimachi K,Higashi H.An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report.

2012;18:2434-2437[DOI:10.3748/wjg.v18.i19.2434]

3 Cording S,Lhermitte L,Malamut G,Berrabah S,Trinquand A,Guegan N,Villarese P,Kaltenbach S,Meresse B,Khater S,Dussiot M,Bras M,Cheminant M,Tesson B,Bole-Feysot C,Bruneau J,Molina TJ,Sibon D,Macintyre E,Hermine O,Cellier C,Asnafi V,Cerf-Bensussan N;CELAC network.Oncogenetic landscape of lymphomagenesis in coeliac disease.

2021[PMID:33579790 DOI:10.1136/gutjnl-2020-322935]

4 Huang L,Liu D,Wang N,Ling S,Tang Y,Wu J,Hao L,Luo H,Hu X,Sheng L,Zhu L,Wang D,Luo Y,Shang Z,Xiao M,Mao X,Zhou K,Cao L,Dong L,Zheng X,Sui P,He J,Mo S,Yan J,Ao Q,Qiu L,Zhou H,Liu Q,Zhang H,Li J,Jin J,Fu L,Zhao W,Chen J,Du X,Qing G,Liu H,Liu X,Huang G,Ma D,Zhou J,Wang QF.Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia.

2018;28:172-186[PMID:29148541 DOI:10.1038/cr.2017.146]