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前言【INTRODUCTION】

2018-01-22 05:27:44
中國藥理學與毒理學雜志 2018年1期
關(guān)鍵詞:藥理新藥藥理學

由中國科學技術(shù)協(xié)會海智辦、中國藥理學會、江蘇省科學技術(shù)協(xié)會、連云港市人民政府共同主辦的“2017中國(連云港)國際醫(yī)藥技術(shù)大會”于2017年11月15-17日在江蘇省連云港市召開。本次會議邀請了300多位中外專家學者,安排了大會報告、中美論壇及中歐論壇等多種形式交流。會議期間,中國藥理學會中藥與天然藥物藥理專業(yè)委員會與江蘇康緣藥業(yè)股份有限公司共同舉辦了“中藥新藥及健康產(chǎn)品研發(fā)與國際化發(fā)展論壇”,由中國藥理學會理事長兼中藥與天然藥物藥理學專業(yè)委員會主任委員張永祥研究員、中國藥理學會前任理事長兼中藥與天然藥物藥理專業(yè)委員會副主任委員杜冠華和江蘇康緣藥業(yè)股份有限公司董事長肖偉擔任論壇共同主席。張永祥研究員致開幕辭,對前來參加論壇的國內(nèi)外專家、有關(guān)部門領(lǐng)導和代表表示熱烈歡迎!指出中藥和健康產(chǎn)品在防治疾病中均具有明顯特色和優(yōu)勢,二者具有密切的關(guān)系。許多健康產(chǎn)品都是基于藥食同源的中藥研制的,在研發(fā)理念、思路和方法上也有共同之處。論壇的目的是結(jié)合國家“重大新藥創(chuàng)制”科技重大專項的實施,為從事中藥新藥研發(fā)和健康產(chǎn)品研發(fā)的國內(nèi)外專家和代表提供一個同臺交流的平臺,就中藥、天然藥物新藥和健康產(chǎn)品研發(fā)的新理念、新思路、新方法、新成果、新經(jīng)驗等進行深入交流,共同研討新產(chǎn)品研發(fā)及國際化發(fā)展的關(guān)鍵問題。希望通過此次論壇,為不斷提高中藥、天然藥物新藥和健康產(chǎn)品的研發(fā)水平和產(chǎn)品質(zhì)量,擴大在世界范圍內(nèi)的應(yīng)用發(fā)揮積極推動作用,同時希望能夠為進一步建立和加強國際合作發(fā)揮積極推動作用?!綯he 2017 China(Lianyungang)International Medical Technology Conference was held in Lianyungang,Jiangsu Province,during November 15-17,which was jointly sponsored by the Office of"HOME Program"of China Association for Science and Technology,Chinese Pharmacological Society(CNPHARS),Jiangsu Association for Science and Technology and the Municipal Government of Lianyungang.This conference invited more than 300 experts from home and abroad and arranged various forms of communication including a symposium,the Sino-American Forum and Sino-European Forum.During the conference,the Division for Traditional Chinese Medicine and Natural Products Pharmacology of CNPHARS and Jiangsu Kanion Pharmaceutical Co.,Ltd.jointly sponsored the Forum on the R&D and Internationalization of New Drugs and Health Products of Traditional Chinese Medicine,which wasco-chaired by ProfessorZHANG Yong-xiang,Presidentof CNPHARS and Chair of Division for Traditional Chinese Medicine and Natural Products Pharma?cology of CNPHARS,Professor DU Guan-hua,former President of CNPHARS and Vice-Chair of Division for Traditional Chinese Medicine and Natural Products Pharmacology of CNPHARS,and Dr.XIAO Wei,Chairman of the Board of Jiangsu Kanion Pharmaceutical Co.,Ltd.Professor ZHANG Yong-xiang delivered the opening speech and expressed warm welcome to every partici?pant of the forum.He said that both traditional Chinese medicine(TCM)and health products had distinct properties and superiority in preventing and treating diseases,and they were closely related.Many health products were developed from the TCM with"the homology of medicine and food"so that there was something in common between TCM and health products on the views and methods of R&D.The forum was intended to create a platform for domestic and overseas experts to exchange new ideas,new thoughts,new approaches,new findings and new experience as well as discuss key problems in R&D of new drugs of TCM and health products with the implementation of National Science and Technology Major Project for Drug Innovation(Drug Innovation Major Project).Professor ZHANG expressed the hope that this forum can play an active role in improving the level of R&D and quality of new drugs of TCM,natural products and health products,contributing to wider use of these products worldwide and strengthening international cooperation in this field.】

國家衛(wèi)生和計劃生育委員會科技教育司重大專項處顧金輝處長在講話中首先對論壇的召開表示祝賀,然后介紹了國家“重大新藥創(chuàng)制”科技重大專項支持中藥新藥研發(fā)的情況。指出自重大專項實施以來,針對中藥新品種研發(fā)、大品種改造、中藥關(guān)鍵技術(shù)研究及中藥大平臺建設(shè)等進行了系統(tǒng)部署,取得了一系列重大成果,包括一批高質(zhì)量中藥新藥品種獲準上市;技術(shù)提升了一批中藥大品種,實現(xiàn)了中藥大品種做大做強的目標;中藥國際化注冊不斷提速;國內(nèi)專家研究制定的多項中藥標準被納入歐美藥典;中藥新藥研發(fā)能力得到明顯提升。期待通過重大專項的實施和中醫(yī)藥學界的努力,使中藥的國際化發(fā)展在“十三五”階段有新的突破和成果,希望與會專家能在本次論壇中多為中藥創(chuàng)新藥研發(fā)及國際化發(fā)展出謀劃策,并為重大專項實施過程中的不足提出意見和建議。【GU Jin-hui,Chief of the Division of National Science and Technology Major Project for Drug Innovation,Department of Health Science,Technology and Education,National Health and Family Planning Commission of the People′s Republic of China(PRC),first expressed congratulations on the opening of this forum,then he introduced the supporting for TCM by Drug Innovation Major Project.He said that since the implementation of Drug Innovation Major Project,the R&D of new drugs of TCM,transformation of TCM grant variety,research on key technologies and the mega platform for TCM have been system?atically planned.As a result,some high-quality and new drugs of TCM have been approved for marketing,and a batch of important drugs of TCM has been upgraded and made dominating.In addition,registration of TCM drugs has been accelerated abroad,standards for drugs of TCM formulated by Chinese experts have been included in European and American Pharmacopoeia and the ability of R&D of TCM new drugs has been improvedsignificantly.Heexpectedthatthe implementation of Drug Innovation Major Project and the effort of TCM would lead to new break?throughs and fruits of the internationalization of TCM during the Thirteenth Five-year Plan Period of PRC.He hoped that the experts present at the forum could give advices on the R&D and inter?nationalization ofdrugsofTCM and make comments on the deficiency of Drug Innovation Major Project.】

本次論壇分2個階段。第一階段是專題報告,由中國藥理學會秘書長兼中藥與天然藥物藥理專業(yè)委員會常務(wù)委員張永鶴教授和中國藥理學會副秘書長、中藥與天然藥物藥理專業(yè)委員會副主任委員兼秘書長周文霞研究員共同主持,6位國內(nèi)外專家就中藥新藥及健康產(chǎn)品研發(fā)與國際化發(fā)展等問題做專題報告。國際藥理學聯(lián)合會(International Union of Basic&Clinical Pharmacology,IUPHAR)秘書長Michael SPEDDING教授作了題為“IUPHAR and world-wide initiatives on natural medicines:the quest for evidence-based medicine”的報告,主要介紹了IUPHAR在天然藥物研發(fā)方面的理念及研究概況,特別介紹了天然藥物在抗炎免疫方面的進展;韓國藥理學會理事長金仁謙教授做了題為“Flavonoids in cardiovascular health”的報告,主要介紹了黃酮在維護心血管健康方面的研究進展;中國藥理學會前理事長杜冠華教授作了題為“How to make TCM benefit the world”,重點介紹了中藥新藥的研究及來源于中藥黃芩的新藥百克利抗帕金森病的研究進展;IUPHAR天然藥物藥理分委會副主席Valérie SCHINI-KERTH教授作了題為“Natural products for healthy ageing”的報告,重點介紹了天然藥物在抗衰老方面的研究進展;英國Robert Gordon大學天然藥物研究中心主任Cherry WAINWRIGHT教授作了題為“Natural product drug&nutraceutical discovery:converging industries”的報告,主要介紹了天然藥物與營養(yǎng)食品在英國的研究現(xiàn)狀;最后,江蘇康緣藥業(yè)股份有限公司張怡博士作了題為“Functions of Ginkgo Diterpene Lactone Meglumine(GDLM)for treatment of ischemic stroke”的報告,主要介紹了江蘇康緣藥業(yè)股份有限公司的新藥銀杏二萜內(nèi)酯葡胺注射液治療缺血性卒中的研究進展?!綯he forum had two stages.Stage one was a symposium which was co-chaired by Professor ZHANG Yong-he,Secretary-General of CNPHARS and Standing Member of the Division for Traditional Chinese Medicine and Natural Prod?ucts Pharmacology and Professor ZHOU Wen-xia,Deputy Secretary-General of CNPHARS and Secretary-General of the Division for Traditional Chinese Medicine and Natural Products Pharma?cology.Six experts from domestic and overseas gave presentations on the R&D and international?ization of new drugs of TCM and health prod?ucts.Professor Michael SPEDDING,Secretary-General of IUPHAR,gave a presentation entitled"IUPHAR and World-wide Initiatives on Natural Medicines:the Quest for Evidence-based Medi?cine",which focused on the IUPHAR′s ideas and the general research situation of natural drugs and particularly introduced the progress of the anti-inflammatory action of natural drugs.Professor InKyeom KIM,Director of the Korean Society of Pharmacology,gave a presentation entitled"FlavonoidsinCardiovascularHealth",which was concerned with the research progress of flavo?noids in maintaining cardiovascular health.Professor DU Guan-hua,former President of CNPHARS delivered a speech entitled"How to Make Tradi?tionalChinese Medicine BenefittheWorld",which focused on research of new drugs of TCM and the progress of Bakeli,a new drug derived from Radix Scutellariae for Parkinson disease.Professor Valérie SCHINI-KERTH,Vice-Chair of the Natural Product Section of IUPHAR,gave a presentation entitled"Natural Products for Healthy Ageing",which mainly introduced the research progress of natural products on anti-ageing.Professor Cherry WAINWRIGHT,Director of Centre for Natural Product Drugs of Robert Gordon University,gave a presentation entitled"Natural Product Drug&Nutra?ceutical Discovery:Converging Industries",which outlined the current research on natural product drugs and nutritional foods in the UK.Finally,Dr.ZHANG Yi from Jiangsu Kanion Pharmaceutical Co.,Ltd.gave a presentation entitled"Functions of Ginkgo Diterpene Lactone Meglumine(GDLM)for Treatment of Ischemic Stroke",which described the research progress of GDLM for treatment in ischemic stroke.】

第二階段為綜合討論階段。6位報告專家齊聚臺上,由張永祥研究員主持,針對中藥、天然藥物新藥與健康產(chǎn)品研發(fā)與國際化發(fā)展等相關(guān)問題進行了廣泛、深入的討論,專家們各抒己見、暢所欲言,氣氛非常熱烈。會后,在與會專家的大力支持和共同努力之下,我們將部分專家的觀點和意見進行了整理,而且為了擴大學術(shù)交流范圍,將專家發(fā)言進行了中英文互譯,將譯文放在“【】”內(nèi),以中英文對照的形式予以刊出,希望對于提高我國中藥、天然藥物新藥與健康產(chǎn)品的研發(fā)水平及國際化發(fā)展發(fā)揮積極的推動作用。【The second stage of the forum was in-depth discussions chaired by Professor ZHANG Yong-xiang.Six experts who had given presentations were invited onto the stage for an in-depth discussion on a wide range of issues involving the R&D and internationalization of TCM,new natural drugs and health products.The experts gave their own opinions freely and the atmosphere was quite lively.With the support and effort of the experts,we summarized and translated the viewsand opinionsofsome experts and published them here both in Chinese and English(the translation was put in the"【】")in order to promote the domestic and overseas academic exchanges and play an active role in the improvement of R&D and internationalization of TCM,new natural drugs and health products.】

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