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NK/T細(xì)胞淋巴瘤患者中血漿EB病毒含量檢測及其臨床意義

2014-03-07 15:50劉陽等
中國實(shí)用醫(yī)藥 2014年2期
關(guān)鍵詞:血漿

劉陽等

【摘要】 目的 探討外周血中EB病毒檢測在NK/T細(xì)胞淋巴瘤中的預(yù)后意義。方法 統(tǒng)計(jì)本院治療的結(jié)外鼻型NK/T細(xì)胞淋巴瘤患者56例,

【關(guān)鍵詞】 NK/T細(xì)胞淋巴瘤;血漿;EB病毒檢測

基金項(xiàng)目:河南省科技攻關(guān)項(xiàng)目社會預(yù)研專項(xiàng)(項(xiàng)目編號:20120091007)

作者單位:450008鄭州大學(xué)附屬腫瘤醫(yī)院血液科/河南省腫瘤醫(yī)院血液科

通訊作者:房佰俊 Email:fdation@126.com

目前研究發(fā)現(xiàn)NK/T細(xì)胞淋巴瘤與EB病毒感染關(guān)系密切,尤其是鼻腔NK/T細(xì)胞淋巴瘤病例,80%~100%都存在EB病毒感染[1]。有研究顯示,血漿EBVDNA滴度與疾病的侵襲有關(guān),可以作為一種腫瘤負(fù)荷標(biāo)記,從而對預(yù)后具有一定的指導(dǎo)意義[2]。本研究利用熒光定量PCR技術(shù)檢測外周血中游離EBVDNA拷貝數(shù),分析其在鼻型NK/T細(xì)胞淋巴瘤中表達(dá)的意義。

1 資料與方法

參 考 文 獻(xiàn)

[1] Vande Rijn M, Bhargava V, Molina Kirsch H, et al.Extranodal head and neck lymphomas in Guatemala:high frequency of Epstein Barr virus associated sinonasal lymphomas. Hum Patho l,1997,28(7):834

[2] ZhaoYang Wang,QingFeng Liu,Hua Wang,et al. Clinical implications of plasma EpsteinBarr virus DNAin earlystage extranodal nasaltype NK/Tcell lymphoma patients receiving primary radiotherapy. Blood,2012,120(10):20032010

[3] 劉衛(wèi)平,李甘地,劉永惠,等.鼻NK/T細(xì)胞淋巴瘤15年研究報道.臨床與實(shí)驗(yàn)病理學(xué)雜志,2000,16(2):89

[4] Chan K C, Zhang J, Chan A T, et al. Molecular characterization of circulating EBVDNA in the plasma of nasopharyngeal carcinoma and lymphoma patients.Cancer Res,2003,63(9):20282032

[5] Kim T M, Lee S Y, Jeon Y K, et al. Clinical heterogeneity of extranodal NK/Tcell lymphoma, nasaltype: a national survey of the Korean Cancer Study Group.Ann Oncol,2008,19(8):14771484

[6] Li Y X, Liu Q F, Fang H, et al. Variable clinical presentations of nasal and Waldeyer ring natural killer/Tcell lymphoma.Clin Cancer Res,2009,15(8):29052912

[7] MrazGernhard S,Natkunam Y,Hoppe R T,et alNatural killer/natural killerlike Tcell lymphoma,CD56+, presenting in the skin:all increasingly recognized entity with an aggressive course.J Clin Oncol, 2001(19):21792188

[8] 王虎,李曉江,張世文,等.結(jié)外NK/T細(xì)胞淋巴瘤鼻型臨床研究.中華耳鼻咽喉頭頸外科雜志,2005,40(11):850854

[9] KUO T T,SHIH L Y,TSANG N M.Nasal NK/T cell lymphoma in Taiwan:a clinicopathologic study of 22 cases,with analysis of histologic subtypes,EpsteinBarr virus LMP1 gene association,and treatment modalities.Int J Surg Pathol, 2004, 12(4):375387

[10] XangLan M, ZuLan s, Dan H, et a1Skp2/p27 expression profile is correlated with EpsteinBarr virus status in extranodal nasaltype natural killer cell lymphoma.Transl Res,2008,151(6):303308

[11] Suzuki R, Yamaguchi M, Izutsu K, et al. Prospective measurement of EpsteinBarr virusDNA in plasma and peripheral blood mononuclear cells of extranodal NK/Tcell lymphoma, nasal type.Blood, 2011, 118(23): 60186022

[12] 彭金昀.不同部位和類型惡性淋巴瘤與EBV感染相關(guān)性研究.中國腫瘤臨床,2008,35(20):11451149endprint

【摘要】 目的 探討外周血中EB病毒檢測在NK/T細(xì)胞淋巴瘤中的預(yù)后意義。方法 統(tǒng)計(jì)本院治療的結(jié)外鼻型NK/T細(xì)胞淋巴瘤患者56例,

【關(guān)鍵詞】 NK/T細(xì)胞淋巴瘤;血漿;EB病毒檢測

基金項(xiàng)目:河南省科技攻關(guān)項(xiàng)目社會預(yù)研專項(xiàng)(項(xiàng)目編號:20120091007)

作者單位:450008鄭州大學(xué)附屬腫瘤醫(yī)院血液科/河南省腫瘤醫(yī)院血液科

通訊作者:房佰俊 Email:fdation@126.com

目前研究發(fā)現(xiàn)NK/T細(xì)胞淋巴瘤與EB病毒感染關(guān)系密切,尤其是鼻腔NK/T細(xì)胞淋巴瘤病例,80%~100%都存在EB病毒感染[1]。有研究顯示,血漿EBVDNA滴度與疾病的侵襲有關(guān),可以作為一種腫瘤負(fù)荷標(biāo)記,從而對預(yù)后具有一定的指導(dǎo)意義[2]。本研究利用熒光定量PCR技術(shù)檢測外周血中游離EBVDNA拷貝數(shù),分析其在鼻型NK/T細(xì)胞淋巴瘤中表達(dá)的意義。

1 資料與方法

參 考 文 獻(xiàn)

[1] Vande Rijn M, Bhargava V, Molina Kirsch H, et al.Extranodal head and neck lymphomas in Guatemala:high frequency of Epstein Barr virus associated sinonasal lymphomas. Hum Patho l,1997,28(7):834

[2] ZhaoYang Wang,QingFeng Liu,Hua Wang,et al. Clinical implications of plasma EpsteinBarr virus DNAin earlystage extranodal nasaltype NK/Tcell lymphoma patients receiving primary radiotherapy. Blood,2012,120(10):20032010

[3] 劉衛(wèi)平,李甘地,劉永惠,等.鼻NK/T細(xì)胞淋巴瘤15年研究報道.臨床與實(shí)驗(yàn)病理學(xué)雜志,2000,16(2):89

[4] Chan K C, Zhang J, Chan A T, et al. Molecular characterization of circulating EBVDNA in the plasma of nasopharyngeal carcinoma and lymphoma patients.Cancer Res,2003,63(9):20282032

[5] Kim T M, Lee S Y, Jeon Y K, et al. Clinical heterogeneity of extranodal NK/Tcell lymphoma, nasaltype: a national survey of the Korean Cancer Study Group.Ann Oncol,2008,19(8):14771484

[6] Li Y X, Liu Q F, Fang H, et al. Variable clinical presentations of nasal and Waldeyer ring natural killer/Tcell lymphoma.Clin Cancer Res,2009,15(8):29052912

[7] MrazGernhard S,Natkunam Y,Hoppe R T,et alNatural killer/natural killerlike Tcell lymphoma,CD56+, presenting in the skin:all increasingly recognized entity with an aggressive course.J Clin Oncol, 2001(19):21792188

[8] 王虎,李曉江,張世文,等.結(jié)外NK/T細(xì)胞淋巴瘤鼻型臨床研究.中華耳鼻咽喉頭頸外科雜志,2005,40(11):850854

[9] KUO T T,SHIH L Y,TSANG N M.Nasal NK/T cell lymphoma in Taiwan:a clinicopathologic study of 22 cases,with analysis of histologic subtypes,EpsteinBarr virus LMP1 gene association,and treatment modalities.Int J Surg Pathol, 2004, 12(4):375387

[10] XangLan M, ZuLan s, Dan H, et a1Skp2/p27 expression profile is correlated with EpsteinBarr virus status in extranodal nasaltype natural killer cell lymphoma.Transl Res,2008,151(6):303308

[11] Suzuki R, Yamaguchi M, Izutsu K, et al. Prospective measurement of EpsteinBarr virusDNA in plasma and peripheral blood mononuclear cells of extranodal NK/Tcell lymphoma, nasal type.Blood, 2011, 118(23): 60186022

[12] 彭金昀.不同部位和類型惡性淋巴瘤與EBV感染相關(guān)性研究.中國腫瘤臨床,2008,35(20):11451149endprint

【摘要】 目的 探討外周血中EB病毒檢測在NK/T細(xì)胞淋巴瘤中的預(yù)后意義。方法 統(tǒng)計(jì)本院治療的結(jié)外鼻型NK/T細(xì)胞淋巴瘤患者56例,

【關(guān)鍵詞】 NK/T細(xì)胞淋巴瘤;血漿;EB病毒檢測

基金項(xiàng)目:河南省科技攻關(guān)項(xiàng)目社會預(yù)研專項(xiàng)(項(xiàng)目編號:20120091007)

作者單位:450008鄭州大學(xué)附屬腫瘤醫(yī)院血液科/河南省腫瘤醫(yī)院血液科

通訊作者:房佰俊 Email:fdation@126.com

目前研究發(fā)現(xiàn)NK/T細(xì)胞淋巴瘤與EB病毒感染關(guān)系密切,尤其是鼻腔NK/T細(xì)胞淋巴瘤病例,80%~100%都存在EB病毒感染[1]。有研究顯示,血漿EBVDNA滴度與疾病的侵襲有關(guān),可以作為一種腫瘤負(fù)荷標(biāo)記,從而對預(yù)后具有一定的指導(dǎo)意義[2]。本研究利用熒光定量PCR技術(shù)檢測外周血中游離EBVDNA拷貝數(shù),分析其在鼻型NK/T細(xì)胞淋巴瘤中表達(dá)的意義。

1 資料與方法

參 考 文 獻(xiàn)

[1] Vande Rijn M, Bhargava V, Molina Kirsch H, et al.Extranodal head and neck lymphomas in Guatemala:high frequency of Epstein Barr virus associated sinonasal lymphomas. Hum Patho l,1997,28(7):834

[2] ZhaoYang Wang,QingFeng Liu,Hua Wang,et al. Clinical implications of plasma EpsteinBarr virus DNAin earlystage extranodal nasaltype NK/Tcell lymphoma patients receiving primary radiotherapy. Blood,2012,120(10):20032010

[3] 劉衛(wèi)平,李甘地,劉永惠,等.鼻NK/T細(xì)胞淋巴瘤15年研究報道.臨床與實(shí)驗(yàn)病理學(xué)雜志,2000,16(2):89

[4] Chan K C, Zhang J, Chan A T, et al. Molecular characterization of circulating EBVDNA in the plasma of nasopharyngeal carcinoma and lymphoma patients.Cancer Res,2003,63(9):20282032

[5] Kim T M, Lee S Y, Jeon Y K, et al. Clinical heterogeneity of extranodal NK/Tcell lymphoma, nasaltype: a national survey of the Korean Cancer Study Group.Ann Oncol,2008,19(8):14771484

[6] Li Y X, Liu Q F, Fang H, et al. Variable clinical presentations of nasal and Waldeyer ring natural killer/Tcell lymphoma.Clin Cancer Res,2009,15(8):29052912

[7] MrazGernhard S,Natkunam Y,Hoppe R T,et alNatural killer/natural killerlike Tcell lymphoma,CD56+, presenting in the skin:all increasingly recognized entity with an aggressive course.J Clin Oncol, 2001(19):21792188

[8] 王虎,李曉江,張世文,等.結(jié)外NK/T細(xì)胞淋巴瘤鼻型臨床研究.中華耳鼻咽喉頭頸外科雜志,2005,40(11):850854

[9] KUO T T,SHIH L Y,TSANG N M.Nasal NK/T cell lymphoma in Taiwan:a clinicopathologic study of 22 cases,with analysis of histologic subtypes,EpsteinBarr virus LMP1 gene association,and treatment modalities.Int J Surg Pathol, 2004, 12(4):375387

[10] XangLan M, ZuLan s, Dan H, et a1Skp2/p27 expression profile is correlated with EpsteinBarr virus status in extranodal nasaltype natural killer cell lymphoma.Transl Res,2008,151(6):303308

[11] Suzuki R, Yamaguchi M, Izutsu K, et al. Prospective measurement of EpsteinBarr virusDNA in plasma and peripheral blood mononuclear cells of extranodal NK/Tcell lymphoma, nasal type.Blood, 2011, 118(23): 60186022

[12] 彭金昀.不同部位和類型惡性淋巴瘤與EBV感染相關(guān)性研究.中國腫瘤臨床,2008,35(20):11451149endprint

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