NA Xiao-dong，WU Wei-kang

(Department of Pathophysiology，Zhongshan School of Medicine，Sun Yat-sen University，Guangzhou 510080，China)

As the bridge of basic and clinical medicine courses，the teaching goal of pathophysiology is to guarantee the medical students with the ability to analyze and solve the practical problems of clinical work．The training of clinical thinking is an important part in the teaching of pathophysiology．The basic mechanism of diseases，being the key content in the course，is also one of the most active fields in medical research．How to arouse the students'interest and their creative thinking is another important issue in the instructional design of pathophysiology．Integrated thinking training on both clinical and scientific research has been explored by problem-based situation teaching，web-based independent study and exploratory experiments in our teaching program．The analytical and application ability could be improved by the problem-based situation teaching．Expanded view on medical research by web-based independent study arouses the students'interest and their creative thinking．Exploratory experiments provide the practice platform to test whether their ideas are workable．