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Table of Contents

157 Programmed cell death ligand-1 （PD-L1）expression by immunohistochemistry: could it be predictive and/or prognostic in non-small cell lung cancer？

Mari Mino-Kenudson

171 Immuno-oncology combinations: raising the tail of the survival curve

Samuel J. Harris， Jessica Brown， Juanita Lopez，Timothy A. Yap

194 Nonmuscle invasive bladder cancer: a primer on immunotherapy

Mahir Maruf， Sam J. Brancato， Piyush K. Agarwal

206 Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward？

Yu-Ling Li， Hua Zhao， Xiu-Bao Ren

215 Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Jay Hocking， Sridurga Mithraprabhu， Anna Kalff，Andrew Spencer

226 New generation of breast cancer clinical trials implementing molecular profiling

Dimitrios Zardavas， Martine Piccart-Gebhart

236 Genetic and molecular changes in ovarian cancer Robert L Hollis， Charlie Gourley

248 Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

Hong-Sheng Zhou， Bing Z. Carter， Michael Andreeff

260 Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients

Wen-Ya Zhou， Hong Zheng， Xiao-Ling Du， Ji-Long Yang

269 Influence of obesity and bariatric surgery on gastric cancer

Anna Carolina Batista Dantas， Marco Aurelio Santo，Roberto de Cleva， Rubens Ant?nio Aissar Sallum，Ivan Cecconello

ORIGINAL ARTICLE

277 Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies

Wei Liao， Sanjai Sharma

286 The oncofetal protein IMP3 is an indicator of early recurrence and poor outcome in mucoepidermoid carcinoma of salivary glands

Mohamed R. Elshafey， Rehab A. Ahmed，Mohamed I Mourad， Essam T. Gaballah

REVIEW